Structure of PDB 6hcv Chain B

Receptor sequence
>6hcvB (length=479) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
PRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLE
DTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAE
CYDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKGLTEI
RYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIA
ANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGI
DNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTYKISYNKDG
PENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFDSNETIEKMINIIKE
HKIELPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKP
GLTERLEMFICGKEVLNAYTELNDPFKQKECFKLAFCTSLEYGLPPTGGL
GLGIDRITMFLTNKNSIKDVILFPTMRPA
3D structure
PDB6hcv Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FYE B R330 E332 H338 N339 F342 E500 G554 R559 R246 E248 H254 N255 F258 E414 G451 R456 MOAD: ic50=0.005uM
PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hcv, PDBe:6hcv, PDBj:6hcv
PDBsum6hcv
PubMed30894487
UniProtQ8IDJ8

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