Structure of PDB 6haz Chain B

Receptor sequence
>6hazB (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
PNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIRK
PVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVL
QSVFKSARQKIAK
3D structure
PDB6haz BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainB
Resolution1.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FX5 B V1408 F1409 L1412 Y1421 A1460 F1463 N1464 I1470 V31 F32 L35 Y44 A83 F86 N87 I93 PDBbind-CN: -logKd/Ki=7.00,Kd=100nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6haz, PDBe:6haz, PDBj:6haz
PDBsum6haz
PubMed31178587
UniProtP51531|SMCA2_HUMAN Probable global transcription activator SNF2L2 (Gene Name=SMARCA2)

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