Structure of PDB 6hay Chain B

Receptor sequence
>6hayB (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
PRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRR
IHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTL
KERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAH
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3D structure
PDB6hay BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainB
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FX8 B W88 Y98 P99 R107 I109 H110 S111 Y112 H115 W117 W30 Y40 P41 R49 I51 H52 S53 Y54 H57 W59 PDBbind-CN: -logKd/Ki=7.01,Kd=98nM
External links
PDB RCSB:6hay, PDBe:6hay, PDBj:6hay
PDBsum6hay
PubMed31178587
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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