Structure of PDB 6h8q Chain B

Receptor sequence
>6h8qB (length=873) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TELFDILSTSEDVSIEELLREWLETYSENRDKFLQEFINLLLNCCGSVAR
VEDHDVHSNESSNETIGEIQLLFQRQKLHEFYLLISKENKKRKNFKMGPL
YQNFAEFMTKLLEVANDLQLLYVGNLVLDLLTWLSSFSVCKIRCFRYIST
LTLYLFQDYLTQQAVNLEKNYLAKLSKQLSLEEKKKRPNNKTLEKLESTI
AETQGSKVVIDSIIDNIVKLCFVHRYKDVSDLIRSESMLHLSIWIKNYPE
YFLKVTFLKYFGWLLSDNSVSVRLQVTKILPHLIIQNSAIRQVFERFKTK
ILEVAIRDVNLDVRIHSIQVLTEASSLGYLDDSEILIISSLMFDEEFDPF
KTSSFNKRSKFLSTVAKFLARVIKEKFDEFIKTHEDLPKEVDGLEVGPVV
QVGIFIKILNDSLIYHLKDCAEVDSRTKIRMLTQAAEFLSPYISTHLKTI
CNLLISDTESNELIPIDRNSTILYLNVFHGLCAGANNPKIQTKDSVKEIV
LPLFYDLLNAASIESADILCPLLESFITFSLDDWISIGYETELKKITDKT
IKAFMDSTIGNSKVDMKYDIFAKFIHHIHHFEKKELQEKFLNQIATLKIH
LKKFLQEKMDPNNSRDDYKDLTCSLYELYINKLTILGRDYPIEVDEELLQ
LFLNNFVSRIPIMFQDFDDSTAQEINFKMLVLLATWNLEKWREIIEKVRK
DLRSVWKPIAAIIGRLNTLVISLAATNETFENINSLFYLKWSACTSLMDI
IVAIKIFELKLPADATTWRYSMSEQFPFYLHDNASKVLLKIFLYLESLFA
KQVDVQLERVADEDANLNDLPETGFFENIETEFLLFTVKLKGLMKLNILD
ERFASRVALNKEKLGPLFKKIVD
3D structure
PDB6h8q Structural basis for Scc3-dependent cohesin recruitment to chromatin.
ChainB
Resolution3.631 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y748 D749 H756 R818 L862 T865 R872 I943 E1017 T1018 L1022 K1026 L1054 Y568 D569 H576 R638 L682 T685 R692 I756 E830 T831 L835 K839 L867
BS02 dna B H427 S507 H282 S354 PDBbind-CN: Kd=2.2uM
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006473 protein acetylation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0034089 establishment of meiotic sister chromatid cohesion
GO:0051301 cell division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0030892 mitotic cohesin complex
GO:0030893 meiotic cohesin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h8q, PDBe:6h8q, PDBj:6h8q
PDBsum6h8q
PubMed30109982
UniProtP40541|SCC3_YEAST Cohesin subunit SCC3 (Gene Name=IRR1)

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