Structure of PDB 6h7o Chain B

Receptor sequence
>6h7oB (length=280) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
AKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVV
GLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRY
LAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQAL
KCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRK
IMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFN
WLGYANSAMNPIIYCRSPDFRKAFKRLLAF
3D structure
PDB6h7o Molecular basis for high-affinity agonist binding in GPCRs.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2CV B V60 I63 A64 V20 I23 A24
BS02 2CV B R104 W109 R64 W69
BS03 P32 B D121 V122 F201 T203 S211 S215 F306 F307 N310 N329 Y333 D81 V82 F161 T163 S171 S175 F227 F228 N231 N250 Y254
BS04 2CV B I224 L289 I184 L210
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6h7o, PDBe:6h7o, PDBj:6h7o
PDBsum6h7o
PubMed31072904
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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