Structure of PDB 6h7n Chain B

Receptor sequence
>6h7nB (length=285) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
AAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLV
VGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDR
YLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQA
LKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIR
KIDRASMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWL
FVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF
3D structure
PDB6h7n Molecular basis for high affinity agonist binding in GPCRs
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2CV B I63 A64 G67 I24 A25 G28
BS02 2CV B R104 W109 R65 W70
BS03 FVK B G98 V102 W117 D121 V122 S211 S215 F306 F307 V326 N329 W330 Y333 G59 V63 W78 D82 V83 S172 S176 F232 F233 V252 N255 W256 Y259
BS04 2CV B T81 S82 K159 T42 S43 K120
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6h7n, PDBe:6h7n, PDBj:6h7n
PDBsum6h7n
PubMed
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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