Structure of PDB 6h7l Chain B

Receptor sequence
>6h7lB (length=285) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
AAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLV
VGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDR
YLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQA
LKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIR
KIDRASMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWL
FVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLAF
3D structure
PDB6h7l Molecular basis for high-affinity agonist binding in GPCRs.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2CV B I63 A64 I24 A25
BS02 2CV B R104 W109 R65 W70
BS03 2CV B T81 K159 W166 T42 K120 W127
BS04 2CV B T81 C85 L93 T42 C46 L54
BS05 Y00 B G98 W117 T118 D121 V122 F201 S211 S215 F306 V326 N329 W330 G59 W78 T79 D82 V83 F162 S172 S176 F232 V252 N255 W256
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6h7l, PDBe:6h7l, PDBj:6h7l
PDBsum6h7l
PubMed31072904
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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