Structure of PDB 6h7e Chain B

Receptor sequence
>6h7eB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
STERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILAL
GHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVEME
EELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAH
LSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGK
GLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRII
3D structure
PDB6h7e GEF regulatory domain
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP B V251 V259 G269 Q270 L271 A272 R279 A280 V195 V203 G213 Q214 L215 A216 R223 A224 BindingDB: Kd=4500nM
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6h7e, PDBe:6h7e, PDBj:6h7e
PDBsum6h7e
PubMed37438343
UniProtO95398|RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (Gene Name=RAPGEF3)

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