Structure of PDB 6h5a Chain B

Receptor sequence
>6h5aB (length=209) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ITTPIARGLLRVGLTPDVVTILGTTASVAGALTLFPMGKLFAGACVVWFF
VLFDMLDGAMARERGGGTRFGAVLDATCDRISDGAVFCGLLWWIAFHMRD
RPLVIATLICLVTSQVISYIKARAEASGLRGDGGFIERPERLIIVLTGAG
VSDFPFVPWPPALSVGMWLLAVASVITCVQRLHTVWTSPGAIDRMAIPGK
GDRENLYFQ
3D structure
PDB6h5a Structure ofMycobacterium tuberculosisphosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis.
ChainB
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D68 D71 D89 D54 D57 D75
BS02 MN B D68 D89 D93 D54 D75 D79
BS03 FLC B S132 K135 E151 R152 R155 R195 S118 K121 E137 R138 R141 R181
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
Biological Process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h5a, PDBe:6h5a, PDBj:6h5a
PDBsum6h5a
PubMed31098408
UniProtP9WPG7|PIPS_MYCTU Phosphatidylinositol phosphate synthase (Gene Name=pgsA1)

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