Structure of PDB 6h45 Chain B

Receptor sequence
>6h45B (length=392) Species: 9606 (Homo sapiens) [Search protein sequence]
SAPRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQ
LDALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQM
VSLVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDV
VSSTVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRA
TCLEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGV
GYATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFG
PIDPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVR
TSIVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
3D structure
PDB6h45 Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.64: tRNA-guanosine(34) queuine transglycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEI B F109 D159 V161 S163 G228 G229 L230 S231 M259 F98 D148 V150 S152 G217 G218 L219 S220 M248
BS02 ZN B C317 C319 C322 H348 C306 C308 C311 H337
BS03 GLU B E141 R184 E130 R173
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex
GO:0120507 tRNA-guanine transglycosylase complex
GO:1990234 transferase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6h45, PDBe:6h45, PDBj:6h45
PDBsum6h45
PubMed30149595
UniProtQ9BXR0|TGT_HUMAN Queuine tRNA-ribosyltransferase catalytic subunit 1 (Gene Name=QTRT1)

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