Structure of PDB 6h22 Chain B

Receptor sequence
>6h22B (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YDAAQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB6h22 Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
ChainB
Resolution2.006 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q24 K51 L54 G58 I61 M62 Y67 Q72 H73 V93 H96 Q8 K35 L38 G42 I45 M46 Y51 Q56 H57 V77 H80
BS02 FL5 B F55 M62 F39 M46
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6h22, PDBe:6h22, PDBj:6h22
PDBsum6h22
PubMed31418442
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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