Structure of PDB 6h0b Chain B

Receptor sequence
>6h0bB (length=521) Species: 9606 (Homo sapiens) [Search protein sequence]
DLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLS
DRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHS
VLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGL
VRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVID
TIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSP
TMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPC
SHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYG
DISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSEC
LDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVP
EQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGR
PDVQMRTCDALDKNQIWSFEK
3D structure
PDB6h0b Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T258 Q269 F284 W286 W334 F364 A368 R372 T201 Q212 F227 W229 W277 F307 A311 R315
BS02 MN B D227 H229 H362 D170 H172 H305
BS03 UDP B A142 F143 D175 R204 G206 L207 D227 C228 H229 W334 Y370 R372 A85 F86 D118 R147 G149 L150 D170 C171 H172 W277 Y313 R315
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h0b, PDBe:6h0b, PDBj:6h0b
PDBsum6h0b
PubMed30276263
UniProtQ8N4A0|GALT4_HUMAN Polypeptide N-acetylgalactosaminyltransferase 4 (Gene Name=GALNT4)

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