Structure of PDB 6gzy Chain B

Receptor sequence
>6gzyB (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
GLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAK
NKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPP
GCRVIEQRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVE
ELETATERYLHVRPQPLPPAYQARLLQKLTEEVPLGQSIPRRRK
3D structure
PDB6gzy Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FHH B Y878 L880 C885 H887 F888 H889 S899 Y20 L22 C27 H29 F30 H31 S41
BS02 ZN B C871 C874 C890 C893 C13 C16 C32 C35
BS03 ZN B C898 C901 H926 C930 C40 C43 H68 C72
BS04 ZN B C911 C916 H923 H925 C53 C58 H65 H67
BS05 ZN B C969 C986 C998 H1001 C102 C112 C124 H127
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6gzy, PDBe:6gzy, PDBj:6gzy
PDBsum6gzy
PubMed30657686
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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