Structure of PDB 6gyr Chain B

Receptor sequence
>6gyrB (length=583) Species: 9606 (Homo sapiens) [Search protein sequence]
AKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK
SPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSK
LSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSY
QNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELF
VECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLP
STRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFV
DSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVY
ISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGD
DYIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDR
LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTPGMPNVSNDLS
QKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFL
TLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD
3D structure
PDB6gyr Transcription factor dimerization activates the p300 acetyltransferase.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1247 C1250 C1272 C203 C206 C228
BS02 ZN B C1183 C1201 C1204 C139 C157 C160
BS03 01K B Y1397 L1398 S1400 R1410 T1411 Y1414 W1436 P1440 Y1446 K1456 I1457 P1458 R1462 L1463 W1466 Y353 L354 S356 R366 T367 Y370 W392 P396 Y402 K412 I413 P414 R418 L419 W422
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6gyr, PDBe:6gyr, PDBj:6gyr
PDBsum6gyr
PubMed30323286
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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