Structure of PDB 6gy2 Chain B

Receptor sequence
>6gy2B (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSSR
3D structure
PDB6gy2 Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
ChainB
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K413 W414 V415 D416 Y417 Y485 H489 L490 L491 H538 K540 K43 W44 V45 D46 Y47 Y115 H119 L120 L121 H168 K170
External links
PDB RCSB:6gy2, PDBe:6gy2, PDBj:6gy2
PDBsum6gy2
PubMed32286328
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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