Structure of PDB 6gmx Chain B

Receptor sequence
>6gmxB (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
MYVKLISSDGHEFIVKREHALTSGTIKAMLSTNEVNFREIPSHVLSKVCM
YFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
3D structure
PDB6gmx Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
ChainB
Resolution2.533 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 F7B B E64 E102 F109 E39 E77 F84 PDBbind-CN: -logKd/Ki=2.17,Kd=6.7mM
BindingDB: Kd=6.7nM
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

View graph for
Biological Process
External links
PDB RCSB:6gmx, PDBe:6gmx, PDBj:6gmx
PDBsum6gmx
PubMed30040896
UniProtQ15369|ELOC_HUMAN Elongin-C (Gene Name=ELOC)

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