Structure of PDB 6gla Chain B

Receptor sequence
>6glaB (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGP
DQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRD
FLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVESEAH
VKIADFGLAKLLPLDKDYYVVRQSPIFWYAPESLSDNIFSRQSDVWSFGV
VLYELFTYCDKSCSPSAEFLRMMERDVPALSRLLELLEEGQRLPAPPACP
AEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
3D structure
PDB6gla Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold.
ChainB
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) A137 A139 R141 N142 D155
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F4B B L828 V836 A853 Y904 L905 C909 R911 D912 R953 L956 L16 V24 A41 Y92 L93 C97 R99 D100 R141 L144 MOAD: ic50=27nM
BindingDB: IC50=0.210000nM,EC50=740nM
BS02 PHU B W1011 M1037 R1059 L1060 W1078 W196 M222 R242 L243 W261
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6gla, PDBe:6gla, PDBj:6gla
PDBsum6gla
PubMed29852068
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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