Structure of PDB 6gky Chain B

Receptor sequence
>6gkyB (length=351) Species: 3442 (Coptis japonica) [Search protein sequence]
QTKKAAIVELLKQLELGLVPYDDIKQLIRRELARRLQWGYKPTYEEQIAE
IQNLTHSLRQMKIATEVETLDSQLYEIPIEFLKIMNGSNLKGSCCYFKED
STTLDEAEIAMLDLYCERAQIQDGQSVLDLGCGQGALTLHVAQKYKNCRV
TAVTNSVSQKEYIEEESRRRNLLNVEVKLADITTHEMAETYDRILVIELF
EHMKNYELLLRKISEWISKDGLLFLEHICHKTFAYHYEPLDDDDWFTEYV
FPAGTMIIPSASFFLYFQDDVSVVNHWTLSGKHFSRTNEEWLKRLDANLD
VIKPMFETLMGNEEEAVKLINYWRGFCLSGMEMFGYNNGEEWMASHVLFK
K
3D structure
PDB6gky Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase.
ChainB
Resolution2.847 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B Y81 S99 G137 C138 G139 N161 Q165 D187 I188 I203 L205 Y75 S93 G131 C132 G133 N155 Q159 D181 I182 I197 L199
BS02 F2Z B E204 F257 F290 E198 F251 F284
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0030776 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6gky, PDBe:6gky, PDBj:6gky
PDBsum6gky
PubMed29791083
UniProtQ948P7

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