Structure of PDB 6g3c Chain B

Receptor sequence
>6g3cB (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA
HRNYSESFFEAASMMSKLSHKHLVLNYGVCENILVQEFVKFGSLDTYLKK
NKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTG
NPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFG
TTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDY
EPDHRPSFRAIIRDLNSL
3D structure
PDB6g3c Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N673 K677 N678 D699
Catalytic site (residue number reindexed from 1) N133 K137 N138 D159
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EKT B L551 G552 L579 K581 Q626 E627 F628 V629 G632 K677 S698 L15 G16 L43 K45 Q86 E87 F88 V89 G92 K137 S158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g3c, PDBe:6g3c, PDBj:6g3c
PDBsum6g3c
PubMed30763067
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

[Back to BioLiP]