Structure of PDB 6g2p Chain B

Receptor sequence

>6g2pB (length=414) Species: 243365 (Chromobacterium violaceum ATCC 12472)

KHSSDICIVGAGISGLTCASHLLDSPACRGLSLRIFDMQQEAGGRIRSKM
LDGKASIELGAGRYSPQLHPHFQSAMQHYSQKSEVYPFTQLKFKSHVQQK
LKRAMNELSPRLKEHGKESFLQFVSRYQGHDSAVGMIRSMGYDALFLPDI
SAEMAYDIVGKHPEIQSVTDNDANQWFAAETGFAGLIQGIKAKVKAAGAR
FSLGYRLLSVRTDGDGYLLQLAGDDGWKLEHRTRHLILAIPPSAMAGLNV
DFPEAWSGARYGSLPLFKGFLTYGEPWWLDYKLDDQVLIVDNPLRKIYFK
GDKYLFFYTDSEMANYWRGCVAEGEDGYLEQIRTHLASALGIVRERIPQP
LAHVHKYWAHGVEFCRDDHPSALSHRDSGIIACSDAYTEHCGWMEGGLLS
AREASRLLLQRIAA

3D structure

• PDB: 6g2p A semi-synthetic strategy for derivatization of the violacein natural product scaffold
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 1.4.3.23: 7-chloro-L-tryptophan oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G13 I14 S15 D38 M39 G45 R46 G61 A62 G63 R64 R207 L208 I241 L267 W359 G362 D389 W397 M398	G12 I13 S14 D37 M38 G44 R45 G60 A61 G62 R63 R206 L207 I240 L266 W358 G361 D385 W393 M394
BS02	TRP	B	R64 H163 Y309 V363 W397	R63 H162 Y308 V362 W393
BS03	MG	B	G11 G13 G16 A240	G10 G12 G15 A239

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0017000 antibiotic biosynthetic process

External links

• PDB: RCSB:6g2p, PDBe:6g2p, PDBj:6g2p
• PDBsum: 6g2p
• UniProt: Q9S3V1|VIOA_CHRVO Flavin-dependent L-tryptophan oxidase VioA (Gene Name=vioA)