Structure of PDB 6g1q Chain B

Receptor sequence
>6g1qB (length=331) Species: 7897 (Latimeria chalumnae) [Search protein sequence]
GPMVSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKA
GTLFYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGV
VQVFKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDV
IKFARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEME
RIEGGKLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYS
FLHCMESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMD
QVTPSWKRSCEAIVETEESAVKLYELYCKQL
3D structure
PDB6g1q (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T62 D63 D64 D305 T56 D57 D58 D283
BS02 AR6 B D63 G101 G103 A104 G105 V106 F129 S134 Y135 G136 N137 G138 H168 D303 T306 D57 G95 G97 A98 G99 V100 F123 S128 Y129 G130 N131 G132 H162 D281 T284
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0060546 negative regulation of necroptotic process
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Cellular Component
External links
PDB RCSB:6g1q, PDBe:6g1q, PDBj:6g1q
PDBsum6g1q
PubMed30472116
UniProtH3BCW1|ADPRS_LATCH ADP-ribosylhydrolase ARH3 (Gene Name=adprs)

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