Structure of PDB 6fzj Chain B

Receptor sequence
>6fzjB (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
NPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDINS
LMMGEDKIKFKHITPLQKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFV
NLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLR
KPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIE
DIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK
KTETDMSLHPLLQEIYKDLY
3D structure
PDB6fzj Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
ChainB
Resolution2.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K329 L339 N340 Q342 V343 L346 L496 E499 K94 L104 N105 Q107 V108 L111 L261 E264
BS02 EDK B F292 F310 C313 Q314 S317 H351 Y355 L358 I369 M376 F391 M392 H477 Y501 F60 F75 C78 Q79 S82 H116 Y120 L123 I134 M141 F156 M157 H242 Y266 BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6fzj, PDBe:6fzj, PDBj:6fzj
PDBsum6fzj
PubMed30651555
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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