Structure of PDB 6fzf Chain B

Receptor sequence
>6fzfB (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM
NSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKS
IPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREF
LKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLN
VKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVMEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB6fzf Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T325 K329 L339 N340 V343 P495 L496 E499 T95 K99 L109 N110 V113 P265 L266 E269
BS02 EDK B F310 G312 C313 Q314 S317 H351 I354 Y355 L358 I369 F391 M392 H477 Y501 F80 G82 C83 Q84 S87 H121 I124 Y125 L128 I139 F161 M162 H247 Y271 BindingDB: Ki=1.4nM,EC50=6.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fzf, PDBe:6fzf, PDBj:6fzf
PDBsum6fzf
PubMed30651555
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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