Structure of PDB 6fu5 Chain B

Receptor sequence
>6fu5B (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHLLDS
ERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLH
RKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEF
HVKIADFGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE
DVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDER
PSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS
3D structure
PDB6fu5 Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
ChainB
Resolution3.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D138 Q142 N143 D156
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E7N B L24 V32 A45 K47 T95 E96 M98 E105 L153 D164 L20 V28 A41 K43 T87 E88 M90 E97 L145 D156
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6fu5, PDBe:6fu5, PDBj:6fu5
PDBsum6fu5
PubMed30026309
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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