Structure of PDB 6fsa Chain B

Receptor sequence
>6fsaB (length=756) Species: 9913 (Bos taurus) [Search protein sequence]
VDAEMAAFGEAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKATI
LSRGKVTAETEHGKTVTVKEDQVLQQNPPKFDKIEDMAMLTFLHEPAVLY
NLKERYASWMIYTYSGLFCVTINPYKWLPVYNAEVVAAYRGKKRSEAPPH
IFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGD
RTGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLA
SADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYD
YAFISQGETTVASIDDAEELMATDNAFDVLGFTTEEKNSMYKLTGAIMHF
GNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVTKGQN
VQQVVYAKGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFE
IFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMD
LQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSSNFQKP
RNIKPEAHFSLIHYAGTVDYNIIGWLQKNKDPLNETVVDLYKKSSLKMLS
SLFANYAGQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDN
PLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPDSRKG
AEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQ
SRGVLS
3D structure
PDB6fsa Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition.
ChainB
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T185 S242 T182 S233
BS02 ADP B N126 P127 X129 W130 S180 G181 G183 K184 T185 V186 N238 N123 P124 X126 W127 S177 G178 G180 K181 T182 V183 N229
Gene Ontology
Molecular Function
GO:0000146 microfilament motor activity
GO:0003774 cytoskeletal motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0007512 adult heart development
GO:0030049 muscle filament sliding
GO:0045214 sarcomere organization
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0016460 myosin II complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0032982 myosin filament

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fsa, PDBe:6fsa, PDBj:6fsa
PDBsum6fsa
PubMed30275503
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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