Structure of PDB 6fs1 Chain B

Receptor sequence
>6fs1B (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB6fs1 Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4Q B F228 M231 V249 M250 V253 R263 T266 L267 F270 G271 F57 M60 V78 M79 V82 R92 T95 L96 F99 G100 MOAD: Kd=0.098uM
BindingDB: Ki=42nM,IC50=42nM,Kd=94nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6fs1, PDBe:6fs1, PDBj:6fs1
PDBsum6fs1
PubMed30559424
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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