Structure of PDB 6frd Chain B

Receptor sequence
>6frdB (length=331) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
TAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRLL
LGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFLY
RGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSASG
NTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDMA
KHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQW
AMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPFF
QKIVDACLQGMQWTVDRIKSNRAQWERVLET
3D structure
PDB6frd Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H673 H709 D710 D822 H87 H123 D124 D236
BS02 E3Q B V840 T841 M861 G873 Q874 F877 V254 T255 M275 G287 Q288 F291
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6frd, PDBe:6frd, PDBj:6frd
PDBsum6frd
PubMed
UniProtQ8WQX9

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