Structure of PDB 6fph Chain B

Receptor sequence

>6fphB (length=441) Species: 294 (Pseudomonas fluorescens) [Search protein sequence]

RQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLAL
AERGAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIW
SINRDRLNRILLDGAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEK
RFHLLIGADGCNSAVRQAMASVVDLGEHLETQPHGYKELQITPEASAQFN
LEPNALHIWPHGDYMCIALPNLDRSFTVTLFLHHQSPASPSFAQLVDGHA
ARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTWHVGGQAVLLGD
AAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQPDALA
IQAMALENYVEMSPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLPYAQ
AMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPL

3D structure

PDB

6fph A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.9: kynurenine 3-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	I12 G15 L16 A17 E36 R37 R38 L54 A55 R110 G133 L134 D165 G166 Y192 G309 D310 G320 Q321 G322 M323 N324	I6 G9 L10 A11 E30 R31 R32 L48 A49 R104 G127 L128 D159 G160 Y186 G299 D300 G310 Q311 G312 M313 N314
BS02	E1W	B	A55 R83 I223 P317 F318 G320 N368 M372 Y403	A49 R77 I217 P307 F308 G310 N358 M362 Y388

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004502	kynurenine 3-monooxygenase activity
GO:0016174	NAD(P)H oxidase H2O2-forming activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0006569	tryptophan catabolic process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process
GO:0019674	NAD metabolic process
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0043420	anthranilate metabolic process
GO:0070189	kynurenine metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6fph, PDBe:6fph, PDBj:6fph
PDBsum	6fph
PubMed	31372510
UniProt	Q84HF5\|KMO_PSEFL Kynurenine 3-monooxygenase (Gene Name=kmo)

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