Structure of PDB 6fhi Chain B

Receptor sequence
>6fhiB (length=750) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNKKMITQ
RTIGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFV
YFVELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTI
TGDNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLG
RGYMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTAS
LSPGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIIN
GHFKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFV
ANFSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFI
KDYRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLR
NLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKS
LEYDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSST
YRRPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
3D structure
PDB6fhi Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R135 N671 R672 S673 I674 N676 R135 N667 R668 S669 I670 N672
BS02 rna B H32 T34 Y38 K188 R190 T201 R203 M356 R365 H32 T34 Y38 K188 R190 T199 R201 M354 R363
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fhi, PDBe:6fhi, PDBj:6fhi
PDBsum6fhi
PubMed
UniProtH6QM91

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