Structure of PDB 6fds Chain B

Receptor sequence
>6fdsB (length=332) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRL
LLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFL
YRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSAS
GNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM
AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQ
WAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPF
FQKIVDACLQGMQWTVDRIKSNRAQWERVLET
3D structure
PDB6fds TbrPDEB1 structure with inhibitor NPD-226
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H673 H709 D710 D822 H88 H124 D125 D237
BS02 D5T B M785 D822 N825 W836 A837 V840 M861 Q874 M200 D237 N240 W251 A252 V255 M276 Q289 BindingDB: Ki=44nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6fds, PDBe:6fds, PDBj:6fds
PDBsum6fds
PubMed
UniProtQ8WQX9

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