Structure of PDB 6fa4 Chain B

Receptor sequence
>6fa4B (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
AFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVI
DGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHY
REQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSA
KTRQGVDDAFYTLVREIRKHKEK
3D structure
PDB6fa4 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
ChainB
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S17 T35 S21 T39
BS02 GNP B G13 G15 K16 S17 A18 V29 D30 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 G17 G19 K20 S21 A22 V33 D34 Y36 P38 T39 G64 N120 K121 D123 L124 S149 A150
BS03 D1W B K5 V7 S39 Y40 R41 D54 L56 Y71 T74 K9 V11 S43 Y44 R45 D58 L60 Y75 T78 MOAD: Kd=0.051uM
PDBbind-CN: -logKd/Ki=7.29,Kd=0.051uM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6fa4, PDBe:6fa4, PDBj:6fa4
PDBsum6fa4
PubMed30093669
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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