Structure of PDB 6fa2 Chain B

Receptor sequence
>6fa2B (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVID
GETCLLDILDTAGHESAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB6fa2 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S17 T35 S20 T38
BS02 GNP B V14 G15 K16 S17 A18 F28 V29 D30 Y32 P34 T35 N116 K117 D119 L120 S145 A146 V17 G18 K19 S20 A21 F31 V32 D33 Y35 P37 T38 N117 K118 D120 L121 S146 A147
BS03 D2W B S39 D54 L56 Y71 T74 S42 D57 L59 Y72 T75
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6fa2, PDBe:6fa2, PDBj:6fa2
PDBsum6fa2
PubMed30093669
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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