Structure of PDB 6f8w Chain B

Receptor sequence
>6f8wB (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
RFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERD
LLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPA
LEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLE
NHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL
ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR
QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPL
WETWADLVHPDAQDILDTLEDNREWYQSTIP
3D structure
PDB6f8w Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
ChainB
Resolution1.601 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H330 H366 D367 D484 H84 H120 D121 D238
BS02 MG B D467 D471 D221 D225
BS03 D0E B M439 L485 T499 I502 F506 M523 Q535 F538 M193 L239 T253 I256 F260 M277 Q289 F292 MOAD: ic50=23uM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6f8w, PDBe:6f8w, PDBj:6f8w
PDBsum6f8w
PubMed29652483
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

[Back to BioLiP]