Structure of PDB 6f8u Chain B

Receptor sequence

>6f8uB (length=325) Species: 9606 (Homo sapiens)

DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPV
DTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLE
ILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFK
LLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVET
KKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEE
FFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVH
PDAQDILDTLEDNREWYQSTIPQAH

3D structure

• PDB: 6f8u Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.
• Chain: B
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H330 H366 D367 D484	H75 H111 D112 D229
BS02	CZQ	B	Y325 M439 N487 Y495 W498 T499 I502 M503 F506 M523 Q535 F538	Y70 M184 N232 Y240 W243 T244 I247 M248 F251 M268 Q280 F283	MOAD: ic50=0.8uM
BS03	CZQ	B	Y325 S374 N487 P488 Y495 W498 T499 I502 M503 F506 M523 Q535 F538	Y70 S119 N232 P233 Y240 W243 T244 I247 M248 F251 M268 Q280 F283	MOAD: ic50=0.8uM

Gene Ontology

Molecular Function

• GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
• GO:0008081 phosphoric diester hydrolase activity

Biological Process

• GO:0007165 signal transduction

External links

• PDB: RCSB:6f8u, PDBe:6f8u, PDBj:6f8u
• PDBsum: 6f8u
• PubMed: 29652483
• UniProt: Q08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)