Structure of PDB 6f8c Chain B

Receptor sequence
>6f8cB (length=394) Species: 448385 (Sorangium cellulosum So ce56) [Search protein sequence]
MDFPLANLFFVPSEDATAFGRRLRAAAQQAPIVFDTAFGMPILLRKSHIT
TAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQY
EERFVRPISEQVVDRLAGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHE
TDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTL
LGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPD
TLARVRQDPSLLPAAIEEGMRWCPSIFGVLRMVERDVRLDDQALSAGTVV
CLAGIAGNYDETAYPSPEVYDIDRKPLPAANVFGGGAHFCVGAPLARMEA
RVGLQALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLPVLLH
3D structure
PDB6f8c Structure-Based Engineering of Steroidogenic CYP260A1 for Stereo- and Regioselective Hydroxylation of Progesterone.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R160 E232 T233 C340 V341 G342
Catalytic site (residue number reindexed from 1) R160 E232 T233 C340 V341 G342
Enzyme Commision number 1.14.15.19: C-19 steroid 1alpha-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B L73 A74 H81 F92 G229 G230 T233 T234 L237 V279 R281 V332 F333 G335 H338 C340 G342 A346 L73 A74 H81 F92 G229 G230 T233 T234 L237 V279 R281 V332 F333 G335 H338 C340 G342 A346
BS02 STR B S225 G229 F277 G278 S225 G229 F277 G278
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f8c, PDBe:6f8c, PDBj:6f8c
PDBsum6f8c
PubMed29509407
UniProtA9FDB7|CP260_SORC5 C-19 steroid 1alpha-hydroxylase (Gene Name=sce1588)

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