Structure of PDB 6f7v Chain B

Receptor sequence

>6f7vB (length=431) Species: 885435 (Streptomyces rochei subsp. volubilis)

VVEAKSRIAVVGGGGSGSVAAWLLARRHDVTLFEADEYLGGHAYSHPVET
DQGTLHVDMGVQHFNEKLSPNLFRLLTDFGIGTYVAPSSVHVDFPGEQQS
WNNLDFLGELREELHEEFDRFHQEMNQLPTSKQMSIGEYLDKHGYSKSFK
YKAMNPILSIYSGCHAPSLDYNLMYVALSFSMNLLSFFSAGYWRKAQGGI
HSYLARIESDLGERVRLNTPVEAVVPTQSGVTVLAGGQEHHFDQVVFATH
ADVTLRLLRTSDQQYRDLLGDFAYVPVESVLHQDESWLSPAGGGAYCQFR
MPEGFELARAEEQMGSLTRNCNVLHPYRKVSSPILITFDPQEDVDPERVI
VRREWKLPQLRPVDVRRKKRLHEIQGLNGLWFCGTDTSVTGHEGAIVSGM
VIADRLGVPHPFPDDAPAAAQFRGIKEFMGV

3D structure

• PDB: 6f7v Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis.
• Chain: B
• Resolution: 3.03 Å

Enzymatic activity

• Enzyme Commision number: 1.4.3.4: monoamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G14 G16 S18 E36 A37 G43 H44 G62 V63 Q64 H65 V228 T256 W362 L364 G391 T392 G398 H399 A402	G12 G14 S16 E34 A35 G41 H42 G60 V61 Q62 H63 V221 T249 W355 L357 G384 T385 G391 H392 A395
BS02	CWH	B	L70 I167 Y168 N179 M181 Y182 F345 V396 T397	L68 I160 Y161 N172 M174 Y175 F338 V389 T390

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:6f7v, PDBe:6f7v, PDBj:6f7v
• PDBsum: 6f7v
• PubMed: 30266997
• UniProt: G4V2H3