Structure of PDB 6f7l Chain B

Receptor sequence

>6f7lB (length=428) Species: 1928 (Streptomyces rochei) [Search protein sequence]

VEAKSRIAVVGGGGSGSVAAWLLARRHDVTLFEADEYLGGHAYSHPVETD
QGTLHVDMGVEHFNEKLSPNLFRLLTDFGIGTYVAPSSVHVDFPGEQQSW
NNLDFLGELREELHEEFDRFHQEMNQLPTQMSIGEYLDKHGYSKSFKYKA
MNPILSIYSGCHAPSLDYNLMYVALSFSMNLLSFFSAGYWRKAQGGIHSY
LARIESDLGERVRLNTPVEAVVPTQSGVTVLAGGQEHHFDQVVFATHADV
TLRLLRTSDQQYRDLLGDFAYVPVESVLHQDESWLSPAGGGAYCQFRMPE
GFELARAEEQMGSLTQNCNVLHPYRKVSSPILITFDPQEDVDPERVIVRR
EWKLPQLRPVDVRRKKRLHEIQGLNGLWFCGTDTSVTGHEGAIVSGMVIA
DRLGVPHPFPDDAPAAAQFRGIKEFMGV

3D structure

PDB

6f7l Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	B	G14 G16 S18 E36 A37 G43 H44 G62 V63 E64 H65 V228 H257 W362 L364 G391 G398 H399 A402	G11 G13 S15 E33 A34 G40 H41 G59 V60 E61 H62 V218 H247 W352 L354 G381 G388 H389 A392
BS02	CA	B	K336 V337	K326 V327
BS03	CWH	B	E64 H65 L70 I167 Y168 Y182 Q326 V396 T397 Q428	E61 H62 L67 I157 Y158 Y172 Q316 V386 T387 Q418

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6f7l, PDBe:6f7l, PDBj:6f7l
PDBsum	6f7l
PubMed	30266997
UniProt	Q83X90

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