Structure of PDB 6f56 Chain B

Receptor sequence
>6f56B (length=382) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLG
DRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGV
RVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLI
REITRRVHLEGIFQAVYTAGVVLPKPVGTCQYFHRSLNPRKLIEVKFSHL
SRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTP
VMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHK
SLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNMVDLMENKTFVEK
LKFGIGDGHLQYYLYNWKCPSMGAEKVGLVML
3D structure
PDB6f56 How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System.
ChainB
Resolution1.9402 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA B Y117 Q118 F119 W120 Y180 V181 I245 N246 L248 C249 V250 R255 S256 R258 A260 I264 T268 F277 A279 Y281 T282 L287 Y479 Y3 Q4 F5 W6 Y66 V67 I131 N132 L134 C135 V136 R141 S142 R144 A146 I150 T154 F163 A165 Y167 T168 L173 Y365
BS02 MG B K257 R258 V259 K143 R144 V145
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6f56, PDBe:6f56, PDBj:6f56
PDBsum6f56
PubMed31423787
UniProtP30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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