Structure of PDB 6f30 Chain B

Receptor sequence
>6f30B (length=722) Species: 10116 (Rattus norvegicus) [Search protein sequence]
WVTEACAQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLH
SKYMRAVYPTKAFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVE
KSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSV
PYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQ
LVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEI
NFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDL
PKRLHYAKNVRIDKVHLMVDRQWLAYRNKGNCEGGTHGYNNEFKSMEAIF
LAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAP
FYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLALQEEEQVNQRLNLNRGE
VSATEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVP
KPGDTSSLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIK
GNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGP
IFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPG
WLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLD
FYQEKTQPVSEILQLKTYLPTF
3D structure
PDB6f30 Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UD1 B D168 K205 A206 F207 N227 L240 W272 P273 Y290 Y321 D326 H330 H374 H483 D24 K61 A62 F63 N83 L96 W128 P129 Y146 Y177 D182 H186 H230 H337
BS02 ZN B D168 D373 H374 D24 D229 H230
BS03 ZN B D326 H330 H483 D182 H186 H337
BS04 CA B D752 N754 D756 H758 D760 D603 N605 D607 H609 D611
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f30, PDBe:6f30, PDBj:6f30
PDBsum6f30
PubMed30022031
UniProtP97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Gene Name=Enpp3)

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