Structure of PDB 6f2t Chain B

Receptor sequence
>6f2tB (length=722) Species: 10116 (Rattus norvegicus) [Search protein sequence]
WVTEACAQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLH
SKYMRAVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVE
KSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSV
PYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQ
LVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEI
NFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDL
PKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEA
IFLAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLK
APFYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLALQGQEEQVNQRLNLN
RGEVSATEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSY
TVPKPGDLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIK
GNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGP
IFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPG
WLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLD
FYQEKTQPVSEILQLKTYLPTF
3D structure
PDB6f2t Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 B T206 D326 H483 T62 D182 H339
BS02 ZN B D168 T206 D373 H374 D24 T62 D229 H230
BS03 ZN B D326 H330 H483 D182 H186 H339
BS04 CA B D752 N754 D756 H758 F759 D760 D603 N605 D607 H609 F610 D611
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6f2t, PDBe:6f2t, PDBj:6f2t
PDBsum6f2t
PubMed30022031
UniProtP97675|ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Gene Name=Enpp3)

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