Structure of PDB 6f28 Chain B

Receptor sequence
>6f28B (length=252) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEI
RLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSK
PFMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKIST
FEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNL
TQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS
GC
3D structure
PDB6f28 ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D242 H245 D237 H240
BS02 ZN B H95 K99 H90 K94
BS03 ZN B E44 K243 E39 K238
BS04 CG8 B Y63 P90 T92 R97 G142 A143 T144 N174 M190 E191 T194 Y58 P85 T87 R92 G137 A138 T139 N169 M185 E186 T189 MOAD: Ki=2.15uM
BindingDB: Ki=2150nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6f28, PDBe:6f28, PDBj:6f28
PDBsum6f28
PubMed29451794
UniProtP42264|GRIK3_RAT Glutamate receptor ionotropic, kainate 3 (Gene Name=Grik3)

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