Structure of PDB 6exi Chain B

Receptor sequence
>6exiB (length=470) Species: 29448 (Bradyrhizobium elkanii) [Search protein sequence]
KPGFTDYIVKDIALADFGRKEISLAETEMPGLMATREEYGPKQPLKGARI
AGSLHMTIQTAVLIETLAALGADIRWVSCNIYSTQDHAAAAIAAAGIPVF
AVKGETLTEYWDYTAKLFDWHGGGTPNMILDDGGDATMLVHAGYRAEQGD
TAFLDKPGSEEEEIFYALVKRLLKEKPKGWFAEIAKNIKGVSEETTTGVH
RLYEMANKGTLLFPAINVNDSVTKSKFDNLYGCRESLVDGIRRGTDVMLS
GKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYEVVTM
EDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQIASLR
NLKWTNIKPQVDEIEFPDKHRIIMLSEGRLVNLGNAMGHPSFVMSASFTN
QTLAQIELFANNKDSKYAKKVYVLPKTLDEKVARLHLAKIGVKLTELRKD
QADYIGVKQEGPYKSDHYRY
3D structure
PDB6exi S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic.
ChainB
Resolution1.918 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H58 S81 S86 D135 E197 N222 K227 D231 N232 C236 H342 H392 S400 Q404
Catalytic site (residue number reindexed from 1) H55 S78 S83 D132 E194 N219 K224 D228 N229 C233 H339 H389 S397 Q401
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN B H58 T60 Q62 D231 H342 L386 H392 M397 H55 T57 Q59 D228 H339 L383 H389 M394
BS02 ADN B G263 E284 V285 T317 N319 I322 G260 E281 V282 T314 N316 I319
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0033353 S-adenosylmethionine cycle
GO:0071269 L-homocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6exi, PDBe:6exi, PDBj:6exi
PDBsum6exi
PubMed29619018
UniProtA0A087WNH6|SAHH_BRAEL Adenosylhomocysteinase (Gene Name=ahcY)

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