Structure of PDB 6evk Chain B

Receptor sequence
>6evkB (length=748) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNMITQRT
IGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYF
VELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITG
DNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRG
YMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLS
PGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGH
FKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVAN
FSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKD
YRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNL
HIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKSLE
YDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYR
RPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
3D structure
PDB6evk Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B N671 R672 S673 I674 N676 N665 R666 S667 I668 N670
BS02 rna B H32 T34 Y38 K188 T201 R203 M356 R365 H32 T34 Y38 K188 T197 R199 M352 R361
BS03 PO4 B R560 R571 R556 R567
BS04 PO4 B G274 N276 G270 N272
BS05 PO4 B W309 N310 F412 N413 S416 S444 W305 N306 F408 N409 S412 S440
BS06 PO4 B N16 R498 N16 R494
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6evk, PDBe:6evk, PDBj:6evk
PDBsum6evk
PubMed29202182
UniProtH6QM91

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