Structure of PDB 6elq Chain B

Receptor sequence

>6elqB (length=630) Species: 129958 (Carboxydothermus hydrogenoformans)

SKLSVDPVIPNLYRKAREEGISTVFDRYEAQQPQCGFGLTGLCCRHCVQG
PCRIDPFGEGPQAGICGATAEVITARNLLRQVTAGAAAHVDHAYDVLEVL
EQIAQGTESYSIKDQEKLKQVAFTLGIDTANKTEQEIVEEMCQIIYRDFA
NSGATPMTYLKANSPRERLETWEKLGVLPRNPDREIREALHQTTMGMDAD
PVNLILKTIRLGLVDGFAGLKLATDLQDIIFGTPQPVVTEANLGVLKEDY
VNIIVHGHVPLLSEKIVEWSRKLEDEAKKAGAKGINLAGICCTGNEVLMR
QGVPLATNFLAQELAIITGAVDLMVVDVQCIMPSLAEIAACYHTRLVTTM
PIVKIPGAEHVPFTTETADEASQQIVRMAIESYQKRNPAKVYIPREKAKV
VAGFSVEAIVKALAKLNPDDPLKPLIDNIVSGNILGVVATVGCNNVKVKH
DWFHIELVKELIKNNVLVVTTGCSAHALAKAGLMDPAAAEWAGEGLRAVL
TAIGTANDLGGPLPPVLHMGSCVDNSRIGDLVIAVANYLKVSPKDLPIAA
SAPEYQHEKALSIGTWAVAMGIMTHLGVVPPVVGSSKVTRILTQDAEALI
GGKFYVETDPYKAAAGIIEHIKAKRALLNL

3D structure

• PDB: 6elq CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2.
• Chain: B
• Resolution: 2.52 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.4: anaerobic carbon-monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	B	C47 C50 Q52 C55 C69 R79	C44 C47 Q49 C52 C66 R76
BS02	SF4	B	C38 F40 G41 C46	C35 F37 G38 C43
BS03	BF8	B	H261 C295 F312 C333 G445 C446 C476 C525 K562	H258 C292 F309 C330 G442 C443 C473 C522 K559

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004601 peroxidase activity
• GO:0016151 nickel cation binding
• GO:0016491 oxidoreductase activity
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding
• GO:0050418 hydroxylamine reductase activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006091 generation of precursor metabolites and energy
• GO:0042542 response to hydrogen peroxide
• GO:0098869 cellular oxidant detoxification

External links

• PDB: RCSB:6elq, PDBe:6elq, PDBj:6elq
• PDBsum: 6elq
• PubMed: 29024326
• UniProt: Q3AE44