Structure of PDB 6ee1 Chain B

Receptor sequence
>6ee1B (length=729) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRGTIPVDHIVA
REAAGAFYERLRELFAARKSITTFGPYSPGQAVSMKRMGIEAIYLGGWAT
SAKGSSTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQHYLRLQMSER
QRAATPAYDFRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP
GTKKCGGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLID
SRADERDQPFLLGATKLDVPSYKSCFLAMVRRFYELGVKELNGHLLYALG
DSEYAAAGGWLERQGIFGLVSDAVNAWREDQQSIDGIFDQVESRFVAAWE
DDAGLMTYGEAVADVLEFGAPEEWRAFAARASLHAARAKAKELADPPWDC
ELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFAE
AIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELGKMGFVFNFITY
GGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGPR
SDAALAASSGRTATTLVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQ
RAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQ
KRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVG
EIIVAEVNHPRIAELLTPDRVALRKLITK
3D structure
PDB6ee1 Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
ChainB
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y104 D123 D177 D179 H204 E206 C215 R252 E459 Q482 S489 S491
Catalytic site (residue number reindexed from 1) Y94 D113 D167 D169 H194 E196 C205 R240 E436 Q459 S466 S468
Enzyme Commision number 4.1.3.1: isocitrate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO B R674 D675 Q676 N677 T678 Q685 R687 M689 T690 T711 D713 N714 Y716 Q717 K720 H724 K764 R639 D640 Q641 N642 T643 Q650 R652 M654 T655 T676 D678 N679 Y681 Q682 K685 H689 K729
BS02 MG B A450 A453 Q482 A427 A430 Q459
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6ee1, PDBe:6ee1, PDBj:6ee1
PDBsum6ee1
PubMed31604954
UniProtQ8VJU4|ACEA2_MYCTO Isocitrate lyase 2 (Gene Name=icl2)

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