Structure of PDB 6edb Chain B

Receptor sequence
>6edbB (length=67) Species: 9606 (Homo sapiens) [Search protein sequence]
KRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFF
QEAQKLQAMHREKYPNY
3D structure
PDB6edb Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
ChainB
Resolution3.209 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K6 R7 M9 N10 I13 R17 R20 N32 K1 R2 M4 N5 I8 R12 R15 N27
BS02 dna B F12 S33 S36 W43 F7 S28 S31 W38
External links
PDB RCSB:6edb, PDBe:6edb, PDBj:6edb
PDBsum6edb
PubMed31142647
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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