Structure of PDB 6ech Chain B

Receptor sequence
>6echB (length=525) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRS
VDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRP
VAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTV
WVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRK
GVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDA
LGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVF
LAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGAD
CIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRD
PTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSA
QAARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGD
LVIVVTGWRPGSGYTNIMRVLSVSH
3D structure
PDB6ech Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
ChainB
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R85 R132 K282 T340
Catalytic site (residue number reindexed from 1) R66 R113 K263 T321
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0001666 response to hypoxia
GO:0006096 glycolytic process
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0010038 response to metal ion
GO:0016310 phosphorylation
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0051591 response to cAMP
GO:0051707 response to other organism
GO:0071872 cellular response to epinephrine stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ech, PDBe:6ech, PDBj:6ech
PDBsum6ech
PubMed31825824
UniProtP12928|KPYR_RAT Pyruvate kinase PKLR (Gene Name=Pklr)

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