Structure of PDB 6eaq Chain B

Receptor sequence

>6eaqB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]

ELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV
EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI
EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE
SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEAL
HNHYTQKSLSLS

3D structure

PDB

6eaq A single amino acid distorts the Fc gamma receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a.

Chain

Resolution

2.22 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	B	F241 F243	F9 F11
BS02	GAL	B	P244 K246 E258 T260	P12 K14 E26 T28

External links

PDB	RCSB:6eaq, PDBe:6eaq, PDBj:6eaq
PDBsum	6eaq
PubMed	30361439
UniProt	P0DOX5\|IGG1_HUMAN Immunoglobulin gamma-1 heavy chain

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