Structure of PDB 6e70 Chain B

Receptor sequence

>6e70B (length=115) Species: 9606 (Homo sapiens)

CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTN

3D structure

• PDB: 6e70 Structural Variants of Transthyretin
• Chain: B
• Resolution: 1.992 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1FL	B	K15 L17 A108 A109 L110 S117 T118	K6 L8 A99 A100 L101 S108 T109	BindingDB: IC50=12000nM,Kd=407nM,EC50=5600nM
BS02	CA	B	E66 D99	E57 D90

Gene Ontology

Molecular Function

• GO:0005179 hormone activity
• GO:0005515 protein binding
• GO:0042802 identical protein binding
• GO:0070324 thyroid hormone binding

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0007165 signal transduction

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6e70, PDBe:6e70, PDBj:6e70
• PDBsum: 6e70
• UniProt: P02766|TTHY_HUMAN Transthyretin (Gene Name=TTR)