Structure of PDB 6e4t Chain B

Receptor sequence
>6e4tB (length=159) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFF
VDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKAPPILP
PHLLQVILNKSCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKY
VTTLLYKPI
3D structure
PDB6e4t Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HTV B R83 T106 S108 V113 R5 T28 S30 V35 PDBbind-CN: -logKd/Ki=8.05,Kd=8.96nM
External links
PDB RCSB:6e4t, PDBe:6e4t, PDBj:6e4t
PDBsum6e4t
PubMed30036059
UniProtP80386|AAKB1_RAT 5'-AMP-activated protein kinase subunit beta-1 (Gene Name=Prkab1)

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